Abstract
ABSTRACTAlongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.
Highlights
Alongside proper diets, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are widely sought after for improved adaptation to physical training
The marketing appeal of these products derives from claims that isolated Branched-chain amino acids (BCAA) intake combined with resistance physical exercise stimulates muscle protein synthesis
This long-standing claim is based on cellular and animal model studies reporting enhanced anabolic intracellular signaling in response to BCAA intake.[3] evidence supporting the efficacy of isolated BCAA intake for muscle hypertrophy in humans is equivocal
Summary
Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review. Consumo isolado de aminoácidos de cadeia ramificada e síntese de proteína muscular em humanos: uma revisão bioquímica. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is examined. O principal marketing está na afirmação de que o consumo isolado de aminoácidos de cadeia ramificada associado ao exercício físico resistido estimula a síntese de proteína muscular. Descritores: Leucina; Valina; Isoleucina; Aminoácidos de cadeia ramificada; Hipertrofia; Músculo esquelético einstein (São Paulo). 2019;17(3):
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