Abstract
Septum pellucidum is a thin midline membrane that separates the anterior horns of the lateral ventricle. Agenesis of septum pellucidum (ASP) is considered a continuum of forebrain maldevelopment. Isolated ASP is a rare radiographic finding of unclear significance. We report a case of a 42-year-old male with ASP who presented with a new-onset seizure and eye closure sensitivity seen in the electroencephalogram. Magnetic resonance imaging of the brain confirmed the ASP. In the absence of data about the association between seizure and ASP, further studies are needed to determine its significance.
Highlights
Septum pellucidum is a midline telencephalic triangular thin membrane separating anterior horns of the right and left lateral ventricles
Agenesis of septum pellucidum (ASP) is regarded as a spectrum of maldevelopment of forebrain structures, which is frequently associated with septo-optic dysplasia (SOD) that consists of a triad of midline brain defects, optic nerve hypoplasia, and hypopituitarism [1,2]
We report an adult patient with isolated ASP that presented with new-onset seizure accompanied by abnormal electro-encephalogram (EEG) findings
Summary
Septum pellucidum is a midline telencephalic triangular thin membrane separating anterior horns of the right and left lateral ventricles. It is made up of glial cells, neurons, fiber bundles, and veins. The patient’s confusion resolved en-route to the hospital His medical history included hypertension, hyperlipidemia, diabetes mellitus, and cerebral palsy. Initial blood workup showed a glucose level of 188 mg/dL (Ref: 70-110 mg/dL), normal complete blood count, and a comprehensive metabolic panel including electrolytes, liver function, and renal function test. His urine toxicology and thyroid function test were unremarkable. On a yearly follow-up, the patient reported being compliant on his medication and seizure-free
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