Isolated ACTH deficiency in childhood: Lack of response to corticotropin-releasing hormone alone and in combination with arginine vasopressin

Abstract

response may be further aggravated by a T-suppressor cell defect, 8 which can now be used to separate histiocytosis X into tumorous and autoimmune subgroups) Vasopressin cell antibodies may prove to be an early marker of hypothalamic invasion in children with histiocytosis X. The association of idiopathic diabetes insipidus with endocrine autoimmune diseases is less marked in children than in adults, perhaps because of the generally later onset of the more common endocrine disorders. Any child with AVP cell antibodies should therefore undergo repeated antibody determinations and endocrine function tests later