Abstract
CONTEXTO: Lesões infectadas de membros inferiores (úlceras diabéticas e úlceras de estase venosa) são causa de grande sofrimento e incapacitação funcional com impacto social, econômico e aumento do risco de complicações severas. OBJETIVO: Caracterizar a microbiota e determinar o perfil de suscetibilidade antimicrobiana das bactérias isoladas de lesões de membros inferiores secundárias a úlcera de estase venosa e pé diabético. MÉTODOS: Foram incluídos no estudo pacientes portadores de lesões de membros inferiores, sendo diabéticos, e pacientes com úlcera de estase venosa, atendidos em um serviço de urgência de um hospital universitário de Goiânia (GO), no período de fevereiro de 2005 a agosto de 2006. A coleta de material foi realizada com swab de algodão para realização de cultura e teste de sensibilidade antimicrobiana, empregando-se técnicas preconizadas. RESULTADOS: Das amostras analisadas, foi detectada a presença de bactérias em 88,46%. Os cocos gram-positivos foram caracterizados como Staphylococcus aureus e Staphylococcus epidermidis. Dentre os bastonetes gram-negativos, detectou-se Pseudomonas aeruginosa,Escherichia coli,Proteus mirabilis e Enterobacter sp. CONCLUSÕES: Os microrganismos isolados das lesões de membros inferiores (pé diabético e úlcera de estase venosa) incluíram bactérias gram-positivas e negativas, sendo Staphylococcus aureus,Pseudomonas aeruginosa e Escherichia coli as mais freqüentes, com elevada resistência a diversos antimicrobianos.
Highlights
Among the most common lower limb lesions are diabetic and venous stasis ulcers.[1]
Plantar lesions known as diabetic foot, a chronic and frequent complication of diabetes mellitus,[1] result especially from neuropathy and degenerative microangiopathy characterized by alteration in capillary structure and protective endothelial function.[2]
Microorganisms associated with lower limb lesions mentioned above are part of skin microbiota, and associations of anaerobic and facultative aerobic bacteria are common, resulting in mixed infections.[9]
Summary
Among the most common lower limb lesions are diabetic and venous stasis ulcers.[1]. Plantar lesions known as diabetic foot, a chronic and frequent complication of diabetes mellitus,[1] result especially from neuropathy and degenerative microangiopathy characterized by alteration in capillary structure and protective endothelial function.[2]. Microorganisms associated with lower limb lesions mentioned above are part of skin microbiota, and associations of anaerobic and facultative aerobic bacteria are common, resulting in mixed infections.[9]. Infected lower limb injuries (diabetic ulcers and venous stasis ulcers) cause great suffering and functional disability with social and economic impact and increase in risk of severe complications. Objective: To characterize the microbiota and determine the antimicrobial susceptibility profile of isolated bacteria in lower limb injuries secondary to the venous stasis ulcer and diabetic foot. Conclusions: Isolated microorganisms of lower limb injuries (diabetic foot and venous stasis ulcer) included Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, which werethemost frequent and highly resistant to several kinds of antimicrobial agents
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