Isogenic models of Parkinson’s disease as a tool for studying the effect of mutation G2019S in LRRK2 gene on calcium signaling

Abstract

Disturbance of calcium signaling is widely observed in various neurodegenerative pathologies including Parkinson's disease (PD). The G2019S mutation in the LRRK2 gene is one of the most common causes of hereditary PD. However, molecular mechanisms of pathological changes remain poorly understood. Recently, intriguing data has been obtained on the effect of the G2019S mutation on the calcium dynamics in the patient-specific dopaminergic neurons. Here we have been studied the effect of this mutation on store-operated calcium entry (SOCE) in isogenic dopaminergic neurons.