Abstract
We used voltage-clamp techniques to assess the effects of isoflurane anaesthesia in slices of sensorimotor cortex of guinea pigs and neonatal rats. Isoflurane (0.5–4%) depressed inward Ca 2+-currents evoked by depolarizing commands from −50 mV. With additional blockade of K +-currents by internal Cs +, an early component of the sustained inward currents was a high voltage-activated current whereas the delayed component was an unclamped Ca 2+-current; this was consistent with a simple compartmental model. Isoflurane decreased the magnitude of the high voltage-activated current.
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