Isoflavone Supplementation Does Not Potentiate the Effect of Combined Exercise Training on Resting and Ambulatory Blood Pressure in Non-Obese Postmenopausal Women: A Randomized Double-Blind Controlled Trial-A Pilot Study.

Juliene G C Dechichi,Jéssica S Giolo,Igor M Mariano,Erick P De Oliveira,Guilherme M Puga,Ana Luiza Amaral,Paula A B Ribeiro,Jaqueline P Batista

doi:10.3390/nu12113495

Juliene G C Dechichi, Jéssica S Giolo + Show 6 more

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https://doi.org/10.3390/nu12113495

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Abstract

Physical exercise and isoflavone supplementation are potential strategies to prevent and treat cardiovascular diseases in postmenopausal women. The aim of this study was to investigate whether there are additive effects of isoflavone supplementation when associated with combined aerobic and resistance exercise on resting and ambulatory blood pressure monitoring (ABPM) and in blood pressure variability (BPV). Thirty-one non-obese postmenopausal women were randomly allocated into two groups: placebo and exercise (Placebo n = 19); and isoflavone supplementation (100 mg/day) and exercise (isoflavone n = 19). ABPM and BPV were evaluated before and after 10 weeks of moderate combined (aerobic and resistance) exercise training. Generalized Estimating Equation (GEE) with Bonferroni correction and intention-to-treat analysis was used to compare the effects of interventions on resting BP, ABPM and BPV. Combined exercise training decreased resting systolic (SBP) and diastolic blood pressure (DBP) and reduced 24 h and awake ambulatory SBP, DBP and mean blood pressure over time, with no additional effects of isoflavone supplementation. No changes were observed in sleep period, or in BPV indexes (Standard Deviation of 24 h (SD), daytime and nighttime interval (SDdn) and average real variability (ARV) in both groups. We conclude that isoflavone supplementation does not potentiate the effects of combined training on resting and ambulatorial systolic and diastolic blood pressure in non-obese postmenopausal women.

Highlights

Several physiological changes occur during the transition period of menopause due to the influences of the aging process, lifestyle and hypoestrogenism [1]
We have previously shown that associating isoflavone supplementation with physical training does not modify markers of oxidative stress in postmenopausal women [16]
There was no difference between the PLA and ISO groups in age, time after menopause, body mass index and physical activity level measured by International Physical Activity Questionnaire (IPAQ) and metabolic equivalent of task (MET)

Summary

Introduction

Several physiological changes (especially in endocrine system) occur during the transition period of menopause due to the influences of the aging process, lifestyle and hypoestrogenism [1]. These factors can lead to an increase in blood pressure (BP) and body mass index, which can intensify the risk. Supplementation with phytoestrogens such as isoflavone (ISO; soy-derived compound) have been used for women in the menopause transition as an alternative to the effects of reduced estrogen production [8]. The use of ISO by postmenopausal women may have benefits in reducing cardiovascular diseases, climacteric symptoms [9] and lipid levels [10]

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