Abstract
In a previous publication on the effect of X-ray dose fractionation on the total dose required to produce radiation myelopathy in rats, we showed that the slope of the Strandqvist-type isoeffect curve between one and 30 fractions to the cervical or lumbar cord was 0.4 (White and Hornsey, 1978). This was in good agreement with the observation of Van der Kogel (1977) on a different strain of rat, who obtained a value of 0.44 between one and 20 fractions. The slopes of these isoeffect curves are all steeper than that for skin damage which is 0.34, decreasing to 0.27 as fractionation is increased (Fowler, 1971). The slope of the curve for radiation myelopathy between four and 30 fractions for fractionation given in the same overall treatment time, which gives the exponent of N in the Ellis formula (total dose αNαTβ, Ellis 1969), was 0.35 (White and Hornsey, 1978). There was no indication of reducing slope with increasing number of fractions at least up to 30 fractions as is seen for both skin damage (Fowler, ...
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