Abstract
Metallophores are low-molecular-weight compounds capable of chelating heavy metals, which have recently been reported to alleviate heavy metal stress in plants. We isolated two undescribed compounds as Zn-chelating metallophores from the culture broth of the root endophytic Pezicula ericae w12-25, which was collected from a Zn-accumulating plant, Aucuba japonica Thunb. These two compounds were determined to be (3aS,4S,6aR)-3a-hydroxy-3-methylene-4-octyldihydrofuro[3,4-b]furan-2,6(3H,4H)-dione and (3S,3aS,4S,6aR)-3a-hydroxy-3-(hydroxymethyl)-4-octyldihydrofuro[3,4-b]furan-2,6(3H,4H)-dione using spectroscopic methods (HRMS, 1H and 13C NMR, and 2D NMR) and X-ray crystallography, respectively. The two compounds, classified as furofurandiones, were named isoavenaciol and 7-hydroxy-isoavenaciol. After the hydrolysis of the lactone moiety, isoavenaciol would release the carboxyl group to show Zn-chelating activity. Their antifungal activities were confirmed using Cladosporium herbarum (AHU9262).
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