Abstract
Obesity is caused by an imbalance of energy intake and physical activity. A number of pharmaceutical agents exist to reduce body weight‐related symptoms of obese patients. Ishige okamurae is brown algae and has anti‐oxidant and anti‐inflammatory activities. However, it has not been reported that Ishige okamurae has anti‐obesity property. In our study, we identified that Ishige okamurae extract (IOE) suppresses high fat diet (HFD)‐induced obesity through modulation of adipogenesis and lipolysis. IOE fed mice decreased body and WAT weight. The expression of adipogenic factors such as CCAAT/enhancer binding protein alpha (C/EBPα) and peroxisome proliferator‐activated receptor gamma (PPARγ) were decreased by IOE. Additionally, IOE up‐regulated expression of lipolysis related enzymes such as adipose triglyceride lipase (ATGL) and hormone‐sensitive lipase (HSL). Therefore, our results suggested IOE suppresses adiposity through reduction of adipogenic and enhance of lipolytic‐related factors.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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