Abstract
Genome-wide association studies (GWAS) have identified > 1000 genetic variants associated with blood pressure (BP) and hypertension. However, the identity of genes mediating these associations and the downstream molecular mechanisms remain largely unknown. Large panels of human kidney tissue characterised at multiple molecular levels together with the newest statistical advances have accelerated translation of GWAS signals into specific kidney mRNA isoforms, genes and pathways causally associated with BP. The lecture will illustrate how the human kidney transcriptomics, epigenomics and proteomics have enhanced our understanding of BP regulation and how they are paving the way to discovery of new diagnostic and therapeutic opportunities for hypertensive patients.
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