Isfahan Thyroid Cohort Study (ITCS).

Samaneh Shahrokh Esfahani,Atoosa Adibi,Rokhsareh Meamar,Sima Aminorroaya Yamini,Majid Abyar,Raheleh Sajad,Aliye Tabatabaee,Mehri Sirous,Ashraf Aminorroaya,Awat Feizi,Azamosadat Tabatabaei,Masoud Amini,Elham Faghih Imani,Mohsen Janghorbani,Rezvan Salehidoost,Silva Hovsepian,Mozhgan Karimifar

doi:10.34172/aim.2021.118

Samaneh Shahrokh Esfahani, Atoosa Adibi + Show 15 more

Open Access

https://doi.org/10.34172/aim.2021.118

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Abstract

The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status. This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020-2021. The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%-90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%-6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%-1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: overt hypothyroidism (2.7, 95% CI: 1.6-3.7), subclinical hypothyroidism (20.6, 95% CI: 18-23), overt hyperthyroidism (1.9, 95% CI: 1-2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6-3.7) per 1000 (person-year). We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection.

Highlights

Thyroid dysfunctions are the most common endocrine disorders after diabetes.[1]
89.3% (2254) of the included subjects were euthyroid, while thyroid disorders were identified in the rest of participants: 2.8% overt hypothyroidism, 5.8% subclinical hypothyroidism, 0.8% overt hyperthyroidism, and 1% subclinical hyperthyroidism.[8]
Hypothyroidism and hyperthyroidism were significantly associated with goiter

Summary

Introduction

Thyroid dysfunctions are the most common endocrine disorders after diabetes.[1]. Thyroid hormones regulate differentiation, growth, and metabolism throughout life.[2]. The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status. Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%–90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%–6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%–1%). Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection.

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Results

Conclusion