Abstract
This chapter describes Immune stimulating complex (ISCOM). ISCOM is a delivery system for antigen and adjuvant together in the same particle. The unique component of ISCOM is a mixture of Quillaja saponins extracted from the bark of the tree Quillaja saponaria Molina. The ISCOM is created to make antigens optimally immunogenic by (1) presenting the antigens in a physically immunogenic form—that is, several copies in a submicroscopic particle to resemble that of an infectious agent, (2) optimizing the targeting of antigen and adjuvant after both mucosal and parenteral modes of administration to lymphatic organs and cells by enclosure of adjuvant and antigen in a stable, uniform particle, and (3) optimizing the immunomodulatory capacity both for neonate and adult immune system by presenting the adjuvant and antigen components in the same particle, reducing the amount of antigen and adjuvant required for efficiently enhancing the immune response.
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