Abstract
Aims: To determine an association between inflammatory and coagulation markers in a COVID-19 patient with ischemic stroke.
 Study Design: We performed a systematic review of 4 databases using the keywords “ischemic”, “stroke”, “COVID-19”,” Virus”
 Place and Duration of Study: December 2021 - January 2022.
 Methodology: Randomised control trials, observational studies, and systematic reviews were evaluated to ascertain the correlation between inflammatory and coagulation markers in COVID-19 patients with Ischemic stroke. Searches were conducted using Cochrane/EMBASE, PubMed/Medline, and PEDro between (2020-2021).
 Results: Of the inflammatory markers, white blood cells (WBC) and platelets did not vary considerably outside their normal ranges. All markers of hypercoagulability were elevated, but only Prothrombin Time corresponded with C-reactive protein (CRP).
 Conclusion: Inflammatory markers were not useful in forecasting the development of acute ischemic stroke, but CRP levels may be a possible marker to further research. D-dimer is a tried and true lab test that should be part of management guidelines in the ongoing COVID pandemic.
Highlights
It's no understatement to state that COVID-19 has become one of the biggest crises of the modern era
The mechanism in which COVID-19 causes ischemic stroke has still yet to be clarified, several theories are given: (a) Coagulopathy resulting from endothelial injury, (b) Frequent presence of anti-phospholipid antibodies [11], and (c) Increased incidence of atrial arrhythmias or myocardial infarctions [12]
Our systematic review differs in that our synthesis aims to look at the different inflammatory markers alongside coagulation markers to determine if there is any linkage/patterns
Summary
It's no understatement to state that COVID-19 has become one of the biggest crises of the modern era. Respiratory involvement is often seen as evidence of the large number of inflammatory cells found in the lung parenchyma [2] Lab investigations in such patients reveal lymphopenia (as opposed to common viral infections that cause lymphocytosis) and an increase in concentrations of pro-inflammatory cytokines such as interleukin 6 (IL-6) [3]. An ischemic stroke should be differentiated from a hemorrhagic stroke which has different pathophysiology Whereas the latter involves rupture of a vessel and consequent bleeding into a closed compartment, the former involves diminished blood supply to the region of interest. The mechanism in which COVID-19 causes ischemic stroke has still yet to be clarified, several theories are given: (a) Coagulopathy resulting from endothelial injury, (b) Frequent presence of anti-phospholipid antibodies [11], and (c) Increased incidence of atrial arrhythmias or myocardial infarctions (which can give birth to an embolus) [12]. Our systematic review differs in that our synthesis aims to look at the different inflammatory markers alongside coagulation markers to determine if there is any linkage/patterns
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