Ischemic stroke as presentation of DADA2: Case report and literature review

Abstract

Deficiency of adenosine deaminase type 2 (DADA2) is a rare monogenic vasculitis syndrome caused by mutations in the ADA2 gene that encodes the adenosine deaminase 2 (ADA2) protein. It is an autosomal recessive disease characterised by a large phenotypic variability due to the many organs that can be affected. Ischemic and/or hemorrhagic stroke could be a manifestation of the disease. We described a case of ischemic stroke as presentation of DADA2.