Abstract
Researchers at the Massachusetts General Hospital, Boston, MA studied retrospectively the risk factors and yield of diagnostic tests, neuroimaging findings, and treatment of ischemic strokes in 215 consecutive young adult patients (aged 18 to 45 years) seen between 2005 and 2010.
Highlights
Treatments in Stroke registries, the Virtual International Stroke Trials Archive, and the US FDA, age alone is not a barrier to thrombolysis with alteplase in adults, but patients over 80 years of age are excluded by European Regulatory Authorities
acute silent cerebral ischemic events (ASCIEs) were detected in 1.3% of MRIs (10 of 771) in 652 children, with an incidence of 47.3 events per 100 patient-years
The authors conclude that children with sickle cell anemia (SCA) experience clinically silent cerebral ischemia far more frequently than previously recognized
Summary
The authors conclude that children with SCA experience clinically silent cerebral ischemia far more frequently than previously recognized. The brain in SCA is at constant threat of ischemic injury. The Nashville experience with neurologic injury in SCA finds that the specific morbidity includes a decrement in general intellectual abilities, poor academic achievement, progression in overt stroke, and new SC infarct despite regular blood transfusion therapy. (De Baun MR et al Blood 2012 May 17;119(20):4587-96) The Nashville experience with neurologic injury in SCA finds that the specific morbidity includes a decrement in general intellectual abilities, poor academic achievement, progression in overt stroke, and new SC infarct despite regular blood transfusion therapy. (De Baun MR et al Blood 2012 May 17;119(20):4587-96)
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