Ischemic signs on the post-resuscitation ECG in absence of STEMI is associated with lower survival. A COACT trial's sub-study

Abstract

Abstract Background The recently published Coronary Angiography after Cardiac arrest (COACT) trial found that urgent coronary angiography did not improve 90-day survival in out-of-hospital cardiac arrest (OHCA) patients without STEMI. The prognostic value of signs of ischemia on the ECG in absence of STEMI, is yet to be determined. Purpose To assess whether ischemic ECG patterns such as ST-depression and T-wave inversion are predictors for survival after OHCA in patients without STEMI. Methods In the COACT trial, patients with return of spontaneous circulation after OHCA with initial shockable rhythm and absence of ST-segment elevation were included. In this sub-study, the first post-resuscitation ECG recorded at the hospital was analysed for signs of ischemia. Ischemia was defined as ST-depression or T-wave inversion >1mm in ≥2 contiguous leads, or both. Primary endpoint was 90-day survival. Secondary endpoints included angiographic outcomes and left ventricular function assessed by cardiac magnetic resonance imaging or echocardiography. Results In total, 552 patients were included in the COACT trial. For this sub-study, 510 OHCA-patients had an ECG available for assessment of whom 340 patients (66.7%) had signs of ischemia on the ECG and 170 patients (33.3%) were without signs of ischemia. Patients with signs of ischemia were significantly older (p=0.003) and more frequently had a history of CAD (p=0.009). Left ventricular ejection fraction was lower in those with signs of ischemia (p=0.007). The number of acute thrombotic occlusions did not differ between groups (p=0.34). Patients with signs of ischemia had a significantly worse 90-day survival compared to patients that showed no signs of ischemia (HR 1.51 (95% CI 1.08–2.12); log-rank p=0.02). Furthermore, larger ST-depression was found to be associated with worse survival (log-rank p=0.01). Neurologic injury was the most common cause of death and its incidence did not differ between the groups (p=0.77). Conclusion Signs of ischemia in absence of STEMI on the post-resuscitation ECG is a predictor for worse survival. Furthermore, a correlation was found between the sum of ST-depression and lower survival rate. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Research grants of Netherlands Heart institue, Biotronic, AstraZeneca Survival plot signs of ischemia on ECGSurvival plot sum of ST-depression