Ischemic degeneration of the avian muscle spindle.

Abstract

The neurovascular supply to the pigeon's extensor digitorum communis muscle was disrupted. The muscle spindles were studied by light and electron microscopy to determine whether their degeneration was compatible with regeneration by activation of satellite cells within an intact spindle capsule. The denervation and ischemia induced intrafusal muscle fiber necrosis and degeneration of the sarcolemma and basal lamina. The muscle fibers in the equatorial region were often absent and their sites were indicated by collagenous caps which usually covered the sensory nerve terminal regions. These collagenous caps enclosed amorphous material derived from the intrafusal fibers and degenerating mitochondria from the sensory terminals. In this equatorial region, the basal lamina was present only under the collagenous cap and was disrupted elsewere . The cells of the muscle spindle capsule were more sparse or absent, but the collagen content had increased. The sheath lacked continuity, containing numerous gaps. These observations indicate that the basal lamina does not remain intact, and regeneration may not occur by activation of satellite cells within the former basal lamina, as reported for regenerating rat muscle spindles. This suggests that the mechanisms of regeneration of muscle spindles in rat and pigeon muscle may not be similar.