Abstract
It is clinically and pathophysiologically important to elucidate the mechanism of cellular injury during hepatic ischemia and subsequent reperfusion. Ischemia-reperfusion injury is complex. Effective prevention strategies will require specific actions during the different phases of ischemia-reperfusion injury, but optimal conditions will only be achieved once the mechanisms of injury at the cellular and molecular levels are understood. It is, therefore, important to study the intracellular signal transduction pathway for its clinical application. This review represents recent advances of the mechanism of hepatic ischemia and reperfusion injury, with special reference to the free radical-mediated injury, the activation of Kupffer cells and neutrophils and the implications of NF-kB activation.
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