Abstract
To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
Highlights
The subtle interruption of the arterial blood supply at any region of the human body promotes a tissue ischemia, which gives initiation of many metabolic alterations in the referred area, causing even a tissue necrosis
The group D, the Sham group, all animals were submitted to analgesy, anesthesia and laparotomy without mesenteric artery occlusion and no one drug have been used for reperfusion
The values from above classification were statistically higher for control group (4.0±1.1) in comparison to PTX (2.5±0.7), prostaglandin E1 (PGE1) (2.1±0.7) and Sham group (0.4±0.5), p=0.0001
Summary
The subtle interruption of the arterial blood supply at any region of the human body promotes a tissue ischemia, which gives initiation of many metabolic alterations in the referred area, causing even a tissue necrosis. To repair this special area it is mandatory a tissue reperfusion. If this subtle interruption occurs partially or in the whole small intestine, with a high intensity, many times it is not possible to maintain even the basal metabolism and, there is cell death and tissue necrosis[1,2,3,4]. The involvement of the muscular layer will disturb the peristaltic movements with consequent stagnation of the intestinal content and increase of the local pressure
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