Abstract
The treatment of invasive fungal infections has deeply evolved in the last years with the inclusion of new antifungals, mainly new azoles (i.e., posaconazole, isavuconazole), to the therapeutic armamentarium. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections both in animals and humans (hematological and non-hematological patients).
Highlights
In the last years, new antifungal drugs have been commercialized, allowing an easier management of invasive fungal diseases (IFD), treatment and outcome
Registrative trials demonstrated that ISV has a similar efficacy to voriconazole for the treatment of invasive aspergillosis and to liposomal amphotericin B for the treatment of mucormycosis [1,16]
Non-registration clinical studies do not attest convincing results in prophylaxis at present, further studies are warranted to explore this type of approach, which would be very attractive in patients receiving as concomitant treatment drugs metabolized via CYP450 and P-glycoprotein efflux pump pathway, given the modest inhibition of the CYP450 system by ISV
Summary
New antifungal drugs have been commercialized, allowing an easier management of invasive fungal diseases (IFD), treatment and outcome. Isavuconazole (ISV) is a new antifungal agent, with a favorable drug-drug interaction profile, reduced drug-related adverse events and efficacy similar to voriconazole for treatment of invasive muld infections, as demonstrated in a non-inferiority trial of IFD treatment [1]. Due to the broad spectrum of action and to its favorable interaction profile, ISV has been proposed as a very effective antifungal drug and, mainly for patients with hematological malignancies (HMs), international guidelines strongly recommended its use for the treatment of invasive aspergillosis and mucormycosis [3,4,5].
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