Abstract
This study evaluated the Xpert MTB/RIF assay for diagnosis of smear-negative childhood pulmonary tuberculosis (TB) using gastric lavage aspirates (GLA) in 211 Chinese children. The sensitivity in detecting children with a clinical diagnosis of TB for MGIT and Xpert was 12.1% (95% CI 9.3%, 14.9%) and 48.6% (95% CI 44.4%, 52.8%), respectively. The authors concluded that Xpert MTB/RIF assay is an excellent tool for the diagnosis of smear-negative childhood with GLA samples. The high proportion of very low mycobacterial load in the GLA samples from smear-negative TB cases may increase the frequency for obtaining indeterminate RIF resistance results by Xpert.
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