Abstract
Background: One of the most common causes of mortality in critical patients admitted to the intensive care unit (ICU) is sepsis. In recent years, the administration of high doses of vitamin C and HAT (hydrocortisone, ascorbic acid and thiamine) therapy has attracted much attention in patients with sepsis.
 Objectives: The current article reviews the beneficial effects of HAT therapy in light of research conducted in this area. Methods: A general search for electronic databases was developed. The human studies of the influence of HAT therapy in critically ill patients were evaluated.
 Results: The results indicated that HAT therapy may improve clinical outcome in septic patients; however, widespread use of these therapeutic approaches in sepsis requires large clinical trials in order to more confidently recommend this therapeutic approach in septic patients admitted to intensive care units.
 Conclusions: HAT therapy may improve clinical outcome in septic critically ill patients.
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