Is Vit D serum concentration related to Italian and Tanzanian breast cancer cases?

Abstract

e22248 Background: The debate on the association between Vit D deficiency and breast cancer risk is still open. Some studies indicate that ethnic differences play a role in the circulating levels of serum Vit D. Moreover, single nucleotide polymorphisms (SNPs) in the Vit D receptor (VDR) have been associated with various types of cancer.The study evaluates Vit D and Binding Protein (DBP) levels, VDR and DBP polymorphisms in Tanzanian and Italian healthy donors (HD) and breast cancer patients (BCP). Methods: The study provides 200 adult women: 100 Tanzanian and 100 Italians (for each population: 50 donors, 25 primary and 25 advanced breast cancer patients). At first, analysis on serum Vit D concentrations has been performed until now on 25 HD and 25 BCP from Italy. The analysis on the overall population is ongoing. All bio-molecular characterization are performed at IRST IRCCS in Italy. The association between Vit D serum concentration and osteoporosis risk factors was evaluated. Results: From Sept to Dec ...