Is there still some reason for classic presentation of Amyotrophic Lateral Sclerosis described in the literature?

Abstract

Obviously, a lot has changed regarding Amyotrophic Lateral Sclerosis (ALS). That old and exemplary definition made by Chacort, of a neurological disease, of a progressive, degenerative and inexorable character, with “isolated” depletion of the upper and lower motor neurons no longer seems so limited to words. ALS is already considered a systemic disease; not only because of new findings that circumvent motor manifestations, but because of genetic codes that signal a form of evolution of hereditary cases.