Is there any role for anti-histamine drug cetirizine in hernioplasty patients?: A case control study

Abstract

Objective: To determine the effect of anti-histamine cetirizine on reducing the drain fluid amount in hernioplasty patients. Method: A retrospective case control study was done in hernioplasty patients with and without cetirizine. The main parameters measured are total mean drain amount, mean drain reduction from day one to two, mean drain amount on day three and drain removal day. Results: Among the 109 participants analyzed, Cetirizine used group (Group I or cases) were 72 clients and the cetirizine deferred control group (Group II or controls) were 37 clients. Drain amount on post-operative day 3 for cases is 15.2 ml and for controls 20.5 ml with significant P value of 0.04. Total mean drain amount till drain removal, drain reduction from day 1 to day2 and mean drain removal day are less for cases but not statistically significant. Conclusion: Cetirizine appears to reduce the drain amount but it needs to be proved by further studies.