Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?

Lütfi Akyol,Kayıhan Karaman,Yunus Keser Yılmaz,Şafak Şahin,Savas Sarıkaya,Elif Börekçi,Fatih Altunkaş

doi:10.4314/ahs.v14i1.41

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke and death. Patients with hypertensive have an increased risk of developing atrial fibrillation. RDW (Red blood cell distribution width) levels are elevated in cardiovascular disorders including heart failure, stable coronary disease, acute coronary syndrome, slow coronary flow and stroke. We aimed to investigate the relation between RDW and AF in patients with hypertensive. We retrospectively examined 126 consecutive hypertensive patients (63 hypertensive patients with AF and 63 hypertensive patients without AF matched with age and sex. The mean age of the study population was 71,09± 8,50 (af group) and 70,97±8,24 (non-af group) years. RDW level was different among patients with atrial fibrillation and without atrial fibrillation.(15,13±1,58 and 14,05±1,15 p<001) . Logistic regression analysis showed that RDW and left atrial dimension were only independently risk factory associated with atrial fibrillation. (Rdw odds ratio:1,846 CI; 1,221-2,793 p<0,05). Roc curve analyses were applied to determine the cut-off point. Cut-off point was at 14,195 and Sensitive, specificity was %71,4, %56 respectively. RDW levels were higher in hypertensive patients with atrial fibrillation. An increased RDW level in the patient with hypertension may alert physician on developing or presence of atrial fibrillation.

Highlights

Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke and death
Several atherosclerotic risk factors, such as obesity, diabetes and hypertension, are associated with development of AF. [1,2,3] Many studies have shown that individuals with hypertension have an increased risk of developing atrial fibrillation compared with normotensive individuals.[4,5,6] Several inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-6, IL-8, and monocyte chemo attractant protein
Correspondence: Savaş Sarikaya MD Department of Cardiology Bozok university, Yozgat Turkey Phone: +903546070 Fax: +903546070 E-mail: cardiology58@gmail.com (MCP)-1 and mediators have been shown associated with the presence or the outcome of AF.[7]. A growing body of literature supports a role for the immune system and chronic inflammation in the development of hypertension.[8; 9] Red blood cell distribution width (RDW) is a measurement of the variability in size of circulating erythrocytes

Summary

Introduction

Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke and death. [1,2,3] Many studies have shown that individuals with hypertension have an increased risk of developing atrial fibrillation compared with normotensive individuals.[4,5,6] Several inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) , interleukin (IL)-2, IL-6, IL-8, and monocyte chemo attractant protein (MCP)-1 and mediators have been shown associated with the presence or the outcome of AF.[7] A growing body of literature supports a role for the immune system and chronic inflammation in the development of hypertension.[8; 9] Red blood cell distribution width (RDW) is a measurement of the variability in size of circulating erythrocytes. RDW (Red blood cell distribution width) levels are elevated in cardiovascular disorders including heart failure, stable coronary disease, acute coronary syndrome, slow coronary flow and stroke. An increased RDW level in the patient with hypertension may alert physician on developing or presence of atrial fibrillation.

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