Abstract
Non-human primate species are considered as good models for human cancer research. Despite the relevant phylogenetic position of prosimians, few reports of neoplastic diseases have been described in these species. The current study investigated implication of an intestinal T-cell lymphoma in a 5-year-old female ring-tailed lemur (Lemur catta) hosted at Parco Natura Viva, an Italian zoological garden. First, a sub-occlusive thickening of the small bowel was found. Histologically, the lesion was caused by a malignant lymphoid infiltrate that was homogeneously CD3+. Moreover, inflammatory patterns peripheral to the lesion suggested a coeliac disease similar to that reported in human. A huge malignant lymphoid infiltrate was present also in the liver and spleen. Overall, the case suggests an etiopathological relationship between coeliac-like disease and intestinal T-lymphoma, as reported in several human studies. Findings from this study are useful to improve our knowledge on the occurrence of the T-lymphoma as well as to improve the husbandry and dietary protocol of prosimians in zoos.
Highlights
The current study investigated implication of an intestinal T-cell lymphoma in a 5-year-old female ring-tailed lemur (Lemur catta) hosted at Parco Natura Viva, an Italian zoological garden
The current study focuses on a case of T-cell intestinal lymphoma in a female ring-tailed lemur (Lemur catta) hosted in Parco Natura Viva, an Italian zoological garden
Findings from the current study are important as they provide useful information on lymphoma in the Lemur catta, Figure 4
Summary
Non-human primates are similar to humans in terms of genetic evolution, immune. NHP species are considered as good models for human cancer research. Due to the low incidence of cancer in non-human primates and the reduced sample size compared to human studies, more data and reports need to be documented, regarding spontaneous tumours [1]. Most studies of cancer in NHPs involved monkeys and great apes [3] [4]. Improving our knowledge on prosimian cancer would be useful to trace the evolution of this disease in humans. The current study focuses on a case of T-cell intestinal lymphoma in a female ring-tailed lemur (Lemur catta) hosted in Parco Natura Viva, an Italian zoological garden
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