Abstract
Cardiovascular diseases and allergic diseases occur commonly in developed countries. They lead to serious health complications and significantly impair the quality of life. Both types of diseases are characterized by excessive inflammatory processes. Recent studies suggest a link between allergy and an increased risk of cardiovascular disease, resulting from overactivity of the immune system in allergic diseases and increased synthesis of proinflammatory mediators, which has been well documented in the pathogenesis of atherosclerosis. The aim of this article is to present current data on the role of proinflammatory factors in the pathogenesis of cardiovascular diseases and allergies and on potential relationship between these disorders.
Highlights
Cardiovascular disease (CVD) is the leading cause of death in developed countries
In spite of differences that could allow to exclude the hypothesis about the relationship between CVD and allergy, it is worth to emphasize that the most important element which seems to link both disorders is excessive pro-inflammatory state – on the one hand responsible for the clinical symptoms of allergy, on the other hand associated with the pathogenesis of atherosclerosis
This results in the inflammatory response - stimulation of endothelial cells, macrophages and vascular smooth muscle cells to produce adhesion molecules (VCAM, ICAM, selectin P and E), which stimulate the recruitment of monocytes into subendothelial space [6]
Summary
Cardiovascular disease (CVD) is the leading cause of death in developed countries. It is estimated that allergies occur in up to 40% of the human population and in more than 80 million Europeans [2,3]. Both groups of diseases, due to the very high prevalence and the possibility of serious complications, contribute to a significant deterioration in patients’ quality of life and their daily and professional activity. Recent studies indicate the role of interleukin-33, a novel member of IL-1 cytokine family, and its receptor ST2 in distinct disease pathologies: promoting Th2 cells-related inflammation in asthma and allergy as well as exerting atheroprotective effect [4]
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