Abstract
Background: The purpose of this study was to evaluate the association between psychological dysfunction and developing complex regional pain syndrome (CRPS) after an ankle fracture. Methods: The PearlDiver database was used to identify patients who sustained an ankle fracture and developed CRPS based on the presence or absence of psychological disorders. Results: Results of the database identified 163,529 patients who sustained an ankle fracture, and CRPS was identified in 10,127 (6.2%) of these patients. The risk of developing CRPS after an ankle fracture was significantly elevated, with an odds ratio (OR) of 5.44 (P<0.0001) in patients with a psychological disorder. There was no additional risk (OR 0.98, P=0.31) for developing CRPS in patients with a psychological disorder who underwent operative management. Conclusions: In patients with known psychological comorbidities who sustain an ankle fracture and have atypical posttraumatic pain, there should be elevated suspicion for CRPS.
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