Is there an association between prostate cancer and human papillomaviruses?

Г М Волгарева

doi:10.17650/1726-9784-2017-16-2-6-12

Г М Волгарева

Open Access

https://doi.org/10.17650/1726-9784-2017-16-2-6-12

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Abstract

Prostate cancer (PC) incidence and mortality are growing steadily the world over including Russia. PC incidence in 2014 made up 14.3 % of all male tumors in the Russian Federation. PC mortality growth rate since 2004 turned out to be topmost among all men’s cancers. PC etiology is poorly understood yet. Thus the role of human papillomaviruses (HPV) belonging to the highly oncogenic types is unclear while in some other human organs they were proven to be powerful carcinogens. Communications keep on emerging from various laboratories by authors who make mutually exclusive conclusions on the role of these viruses in PC genesis. It seems urgent to clarify the given problem from both theoretical and practical viewpoints. Firstly, this is the way to specify the origin of such a common cancer type as PC is. Secondly, if PC association with oncogenic HPV is confirmed the outlook for PC prevention is discovered by means of inoculating of boys with the vaccines designed for cervical cancer prevention. The present review of the literature contains analysis of data on possible HPV involvement in PC genesis.

Highlights

Communications keep on emerging from va rious laboratories by authors who make mutually exclusive conclusions on the role of these viruses in Prostate cancer (PC) genesis
It seems urgent to clarify the given problem from both theoretical and practical viewpoints. This is the way to specify the origin of such a common cancer type as PC is
If PC association with oncogenic human papillomaviruses (HPV) is confirmed the outlook for PC prevention is discovered by means of inoculating of boys with the vaccines designed for cervical cancer prevention

Summary

Introduction

Тип вируса удалось определить в 6 случаях (в 5 образцах РПЖ и 1 контрольном), при этом в 3 из них обнаружено одновременное наличие нескольких типов ВПЧ. В работе была использована смесь моноклональных антител Cervimax, позволяющая обнаруживать онкобелок Е7 всех типов ВПЧ высокого онкогенного риска, а также 4 типов ВПЧ, у которых до настоящего времени онкогенный потенциал в эпителии слизистых оболочек обнаружен не был [27].

Results

Conclusion