Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Emine Arslan,Cihan Togrul,Umit Gorkem

doi:10.21613/gorm.2019.946

Emine Arslan, Cihan Togrul + Show 1 more

Open Access

https://doi.org/10.21613/gorm.2019.946

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Abstract

Objective: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status.Study Design: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment-insulin resistance were assessed.Results: In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p<0.001).Conclusion: No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.

Highlights

Kisspeptin, called metastin, was first discovered from a metastasis suppressor gene, KISS1 in 1996 [1]
No differences were found in serum kisspeptin levels between pregnant women with Gestational diabetes mellitus (GDM) and healthy pregnant women
Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus

Summary

Introduction

Kisspeptin, called metastin, was first discovered from a metastasis suppressor gene, KISS1 in 1996 [1]. Since the time it was first discovered, it has been understood that kisspeptin was involved in many issues including central control of the gonadotropic axis, placentation, pregnancy, energy homeostasis and cardiovascular function [2,3]. Many studies from different fields like cancer biology, repro-. Quick Response Code: Access this article online. How to cite this article: Arslan E. Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? Gynecol Obstet Reprod Med. 2020;26(3):179183 ductive neuroendocrinology, reproductive biology and metabolism have started to focus on kisspeptin Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? Gynecol Obstet Reprod Med. 2020;26(3):179183 ductive neuroendocrinology, reproductive biology and metabolism have started to focus on kisspeptin

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