Abstract
ObjectiveIt is aimed to characterize the true relationship of the cold ischemia time (CIT) with graft survival and with the principal post-transplantation events. Material and methodsWe analyzed 378 kidney transplants, studying the relationship of the CIT with graft survival using a univariate analysis according to the COX model and seeking the optimum cutoff according to the Kaplan–Meier method and log-rank test. The relationship between CIT and the principal events of the post-transplant was studied using the binary logistic regression. ResultsThe mean follow-up of all the group was 77.8 months (±51 SD) and the mean CIT was 14.8h (±5.1 SD). The univariate analysis revealed that the CIT was not related with the graft survival as a continuous variable (OR=1.04; 95% CI: 0.9–1.08; p>0.05). On establishing the cutoff at 18h, we found differences in the actuarial survival. Survival at 5 years was 91% with CIT <18h versus 84% with CIT >18h. Each hour of cold ischemia increased risk of delay in the graft function by 10% (OR=1.1; 95% CI: 1.05–1.15; p<0.001) and also conditioned a greater incidence of acute rejection (41.5% vs. 55.3%; p=0.02) and less time to the first rejection episode (72.6 days±137 vs. 272.2 days±614.8; p=0.023) after 18h. The CIT did not seem to be related (p<0.05) with the rest of the post-transplantation events, such as surgical complications or hospital admissions. ConclusionsIn our experience, cold ischemia under 18h does not seem to negatively affect graft survival.
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