Is There a Role for Concomitant Low-dose Fractionated Radiation Therapy and Chemotherapy in Recurrent or Progressive Glioblastoma?

Abstract

Standardized salvage treatment for recurrent or progressive glioblastoma multiforme (GBM) patients, who previously received radiation therapy plus concomitant and adjuvant temozolomide (TMZ), has not yet been defined. Several in vitro and preclinical studies have demonstrated the hyper-radiosensitivity of human malignant glioma cell lines to low radiation doses and a synergism between low dose fractionated radiation therapy (LD-FRT) and chemotherapy. To evaluate the feasibility and efficacy of this approach in recurrent or progressive GBM, we performed a prospective analysis of concurrent chemotherapy and LD-FRT.