Is there a relationship between serum vaspin levels and insulin resistance in chronic renal failure?

Can Demir,Suleyman Aydin,Ali Gurel,Huseyin Celiker,Akif Dogantekin

doi:10.12669/pjms.35.1.96

Abstract

Objective:Chronic kidney disease (CKD) patients have insulin secretion disorders and resistance to insulin effects, that is responsible for the development of cardiovascular events. Vaspin is an adipocytokine that regulates glucose and lipid metabolism. We aimed to determine the serum vaspin levels and its relationship with insulin resistance in CKD patients.Methods:In the study groups, serum vaspin levels, anthropometric parameters and routine blood tests were measured. The serum vaspin levels were examined by the enzyme-linked immunosorbent assay (ELISA) and insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR) formula.Results:The serum vaspin, HOMA-IR index and insulin levels were observed significantly high in the CKD group in comparison with the control group. No correlation was found between the serum vaspin level and the anthropometric and metabolic values. The serum vaspin level was positively correlated with the fasting plasma glucose and age but without statistical significance.Conclusion:Insulin resistance and hyperinsulinemia contribute to the development of cardiovascular complications in CKD. We consider that the increase in the serum vaspin level is a consequence of the reduced renal excretion in the CKD and increases in response to insulin resistance.

Highlights

Chronic renal disease is defined as the objective renal damage and/or reduction in the glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 for at least three months regardless of the underlying etiology of the renal disease.[1]
homeostasis model assessment of insulin resistance (HOMA-IR) index, insulin, C-peptide and vaspin levels were significantly higher in the Chronic kidney disease (CKD) group than in the control group (p < 0.05)
A significant correlation was found between serum vaspin levels and HbA1c in the CKD group (p < 0.05)

Summary

Introduction

Chronic renal disease is defined as the objective renal damage and/or reduction in the glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 for at least three months regardless of the underlying etiology of the renal disease.[1] In the early stages of CKD, only the functional reserve of the kidney is reduced. Increasing uremia in end-stage renal disease (ESRD) reveals signs and symptoms in almost every organ system defined as the “uremic syndrome”.2. The most common causes of CKD are diabetes mellitus (DM), hypertension, chronic glomerulonephritis, all over the world. Renal replacement therapy should be performed for patients with ESRD.[2,3,4]. Insulin is a polypeptide hormone produced by the beta cells of the pancreas Langerhans islets.[5]

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Conclusion