Is there a Place for ‘Immuno‘ in the Immunotherapy of Multiple Sclerosis?

Abstract

Paolo Muraro Imperial College London, UK some T-cell receptor (TCR) transgenic mouse models develop spontaneous a utoimmune disease [11]. However, there are dissenting views on the role of the immune system in the pathogenesis of MS, with some emphasizing the hypothesis of a primary neurodegenerative component [12]. Arguments that have been raised are that CNS pathology in MS is not always associated with inflammation, that it is often difficult to detect T-cell responses to neuroantigens in MS patients (which are also found in healthy control subjects), and that the genetic associations with immune function genes is relatively weak. Furthermore, EAE may not be a perfect model of MS, but rather a model for acute CNS inflammation [13].