Abstract
Is there a place for anti-nucleosome antibody assessment in scleroderma?
Highlights
The hallmarks of systemic sclerosis (SSc) include microangiopathy, autonomic dysfunction, as well as immune disturbance and the widespread fibrosis of the skin and visceral organs
Secondary objectives included a comparison between SSc, SLE and healthy controls (HC) with respect to autoantibody values, as well as the analysis of the immune disturbance in elderly individuals in the 3 groups
Our cohort consisted of 67 patients with scleroderma, of which 32 were classified as dcSSc (47.8%) while 35 persons presented with lcSSc (52.2%)
Summary
The hallmarks of systemic sclerosis (SSc) include microangiopathy, autonomic dysfunction, as well as immune disturbance and the widespread fibrosis of the skin and visceral organs. Our findings indicate an association between serum anti-nucleosome antibody titers and SSc-related cardiopulmonary involvement. Elderly individuals with scleroderma did not demonstrate a significantly decreased autoantibody production, lupus patients over 60 years of age exhibited a decline in anti-nucleosome antibody titers. Our study confirms the link between anti-nucleosome antibodies and cardiopulmonary involvement in the SSc population. Connective tissue diseases (CTD) constitute a cluster of autoimmune disorders frequently associated with severe multi-organ involvement. Admitting that their intricate pathogenic mechanisms are yet to be fully understood, immune processes remain of paramount importance.
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