Is There a Difference in Response to Dietary Oxidized Oils in Tissues of Pigs of Different Ages?

Abstract

Lipid peroxidation is suggested to have a role in the low‐grade inflammation associated with obesity. The study undertook the examination of the intake of oxidized oils on the oxidative status of liver, muscle and adipose tissues in obese piglets. Glutathione and glutathione reductase and peroxidase were measured in obese pigs from birth to 6 months of age. These oxidative parameters were measured using the assay systems standardized by Cayman Chemical Company, Ann Arbor, Mi. The level of glutathione and the glutathione reductase and peroxidase activities as may have been expected changed with age. The level of glutathione increased with age. In this particular study, the intake of dietary oxidized oils did not seemingly alter the enzyme activities. This could suggest that in this obese line of pigs that were genetically selected for increased dorsal subcutaneous back fat, the dietary intake of oxidized oils was either metabolized in the GI or that it lacked the ability to alter certain metabolic processes that would negatively impact the oxidative status of the cell.