Abstract
Our aim is to clarify if there is an association between the TSI levels and the development of thyroid carcinoma in patients with Grave's disease. A systematic search concerning original studies from 2010 to 2020 was carried out through the databases PubMed, EMBASE and Cochrane, according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. The terms used are 'Graves' disease' and /or 'Incidental Papillary thyroid cancer' and 'TSI' levels. Retrospective studies upon the subject were concluded in the analysis. Only three retrospective studies were found involving 916 patients with Graves' disease and Euthyroid goiter. No significant correlation has been found between TSI and the occurrence of thyroid carcinoma in patients with Graves' disease. Very little research has been conducted upon the subject. More assays are required in order to identify a possible prognostic role of TSI levels in Papillary thyroid carcinoma in patients with Graves disease.
Highlights
Graves’ disease (GD) is an immune system disorder resulting in the overproduction of thyroid hormones and thyrotoxicosis as a result of binding of circulating antibodies to certain thyrotropin receptors
Thyroid-stimulating immunoglobulins (TSI) mimic the action of thyroid stimulating hormone (TSH) and their levels are high in persons with hyperthyroidism due to GD
The aim of this review is to investigate possible correlation of TSI levels in patients with GD to incidental papillary thyroid cancer (PTC) and assess the ability to predict PTC
Summary
Graves’ disease (GD) is an immune system disorder resulting in the overproduction of thyroid hormones and thyrotoxicosis as a result of binding of circulating antibodies to certain thyrotropin receptors. Thyroid-stimulating immunoglobulins (TSI) are immunoglobulins G that bind to and activate the G-protein coupled thyrotropin receptors causing the growth of the thyroid gland and the increased synthesis of thyroid hormones. TSIs mimic the action of thyroid stimulating hormone (TSH) and their levels are high in persons with hyperthyroidism due to GD. The diagnosis of incidental papillary carcinoma in patients submitted to thyroidectomy for a benign disease is quite frequent. According to Pezolla et al, 75% of patients undergoing thyroidectomy for benign disease were diagnosed with thyroid cancer and 18 out of 30 were papillary carcinomas (60%) [2]
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