Abstract
Background: In oral and maxillofacial surgery, synthetic bone grafts are most widely used as bone substitutes, due to the limited sources of autologous bone. The aim of this study was to examine the influence of three different synthetic bone grafts (Cerasorb, Fortoss and Perioglass) on sisters chromatide exchanges (SCEs) in peripheral lymphocytes. Materials and Methods: Peripheral blood samples taken from 68 patients (45 females and 23 males), who underwent oral surgery procedures, such as apical resection, cyst enucleation or periodontal curretage, were obtained for SCE a day before and two months after the surgeries. A control group included 30 patients, while the study group was made of the patients who underwent bone grafting with Cerasorb? (11 patients), Fortoss? VITAL (10 patients) or Perioglass? (17 patients). Results: Comparing with the results of the study group before and after the treatment, it was concluded that the results were statistically significant (p = 0.001). In the Perioglass? subgroup, a greater statistical significance (p = 0.003) was noted, than that in either the Cerasorb? (p = 0.620) or Fortoss? (p = 0.210) subgroups, in which there was no statistical significance. Conclusions: Although further investigations may be necessary, our results suggest that the synthetic bone grafts might have an influence on SCE in peripheral lymphocytes.
Highlights
Bone grafts present different spectrum of organic and syntethic materials that are necessary to provide structural stability and linkage by stimulating osteogenesis, which leads to biological repair of sceletal defects
Conclusions: further investigations may be necessary, our results suggest that the synthetic bone grafts might have an influence on sisters chromatide exchanges (SCEs) in peripheral lymphocytes
The aim of this study was to compare in vivo genotoxic effects of three commercially available synthetic bone graft materials: beta-tri calcium phosphate (Cerasorb®), beta-tricalcium phosphate in a hydroxyl sulphate matrix (Fortoss® VITAL) and bioactive glass ceramic (Perioglass®) by analyzing the frequency of sisters chromatide exchange of peripheral lymphocytes
Summary
Bone grafts present different spectrum of organic and syntethic materials that are necessary to provide structural stability and linkage by stimulating osteogenesis, which leads to biological repair of sceletal defects. Limited autograft quantities and biologic performances, extra donor site surgery including morbidity, as well as infection risk and other complaints, have brought some other materials in use such as alloplasts [1,3,4,5]. These synthetic materials are biocompatible, resorbable, and rapidly replaceable by authentic bone tissue [1,6,7]. The resorption rate is synchronous with bone remodelling [1] Some of these materials are bioactive glasses and calcium phosphates which can be effective for reparation of bone defects in orthopedic and maxillofacial surgery. Conclusions: further investigations may be necessary, our results suggest that the synthetic bone grafts might have an influence on SCE in peripheral lymphocytes
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