Is the tuberculin skin test alone accurate in moderate-to-severe BCG vaccinated patients with inflammatory bowel disease treated with immunosuppressives to test for latent tuberculosis?

Abstract

Background and Aims: There are few data available on effect of immunomodulator/biological therapy on the accuracy of tuberculin skin test (TST, Mantoux skin test) and interferon-gamma release assay (IGRA) in BCG vaccinated immunosuppressed IBD patients. Our aim was to define the accuracy of the TST and IGRA tests in a BCG vaccinated referral IBD cohort treated with immunosuppressives and/or biologicals.