Abstract
AbstractThe state of leucocyte adhesiveness/aggregation (LAA) during stress was determined in 44 rats following sham operation or olfactory bulbectomy. The effects of chronic treatment with the antidepressant desipramine, and calf thymopeptides, on the LAA state and differential white cell count were also studied and compared. In the olfactory bulbectomized rats, LAA percentages and ratios were significantly increased compared with sham operated animals. In the white cell count, the percentage of neutrophils was markedly increased while the percentage of lymphocytes was decreased. Chronic desipramine treatment has no effect on lesioned changes in the LAA and the proportion of white cell. However, thymopeptides significantly reduced LAA percentage and normalized the lymphocyte and neutrophil count in the bulbectomized rats. Such findings further help to valid the olfactory bulbectomized rats as a model of depression and support the view that the state of LAA is a sensitive marker of stress.
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