Abstract
The CT scan allows an accurate morphologic analysis of an 'ARDS' lung. In addition, with the spiral CT it is also possible to perform a quantitative analysis using dedicated software. The quantitative analysis is based on the strict correlation between the X-ray attenuation in a given volume of tissue and the physical density of that volume. The CT is determined by the percentage of radiation that is absorbed by that volume. However, due to the necessity of a manually drawing of the lung (i.e. to include the lung and to exclude big vessels, trachea, pleural effusion, etc.), it would be possible to increase the inaccuracy of the analysis. The aim of this study was to evaluate the accuracy of analysis between trained physicians (four medical doctor) and two radiologists. We enrolled 12 intubated sedated paralyzed patients ALI/ARDS patients (mean age 63.5 ± 16.9 years, BMI 24.1 ± 4.7 m2, tidal volume 532 ± 195 ml, PEEP 11.2 ± 1.9 cmH2O, PaO2/FiO2 205 ± 57). The CT scan was done for clinical purpose, in static conditions, at end expiration 5 or 15 cmH2O PEEP and at end inspiration 45 cmH2O airway pressure. The exposures were taken at 120 KV and 250 mA. The lung volume, weight and the distribution of lung weight between the different parts was measured using the 'Maluna' software (University of Mannheim, Germany). The results show that the quantitative analysis, although requiring a physician to manually draw the region of interest of the lung, presents a high degree of accuracy. Table 1
Highlights
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide
This study shows that the inhibition of the intramyocardial expression of tumour necrosis factor (TNF)-α and of its secondary mediator COX-2 related to moderate hypothermia during cardiopulmonary bypass (CPB) is associated with the inhibition of p38 mitogen-activated protein kinase (MAPK)–acute pancreatitis (AP)-1, but not of the NF-κB pathway
Purification, characterization, and analytical mass assignment of inducible nitric oxide synthase (iNOS) from DLD-1-5B2 cells are in progress to provide mass standardization for the iNOS immunoassay
Summary
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide. Methods Eighty-one consecutive patients (age 63 ± 16 years, male n = 51, SAPS 2 score 49 ± 11, mechanical ventilation n = 50, vasopressors n = 56, renal failure n = 19, postoperative n = 23) admitted to the ICU during a 3-month period were evaluated. Probiotics administration was suggested to reduce the incidence of infections and the overall morbidity and mortality in surgical patients The aim of this prospective randomized clinical trial was to assess the effects of a combination formula of probiotics and prebiotics (Synbiotic 2000Forte; Medifarm, Sweden) versus prebiotics only (fiber) in critically ill, long-term mechanically ventilated trauma patients. This study examines the acute patient outcomes associated with the evolution of early total care to damage control orthopaedics for multiply injured patients with femoral shaft fractures
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