Abstract
Objective:We aimed to investigate the correlation of the size and volume of uterine tumors obtained using positron emission tomography/computed tomography (PET/CT) and pathology specimens in patients with endometrioid-type endometrial cancer (EEC) in the premenopausal period, and to compare the results with those of postmenopausal women. In the premenopausal period, the endometrium uses more glucose than in the postmenopausal period. Therefore, the measurement of uterine tumor size using PET/CT in the premenopausal period may normally be different.Materials and Methods:In this retrospective study, we reviewed the records of patients who were diagnosed as having EEC and underwent hysterectomy. Only patients who underwent preoperative PET/CT imaging were included in the study. The thickness and volume of the uterine lesion, and its maximum standardized uptake value as obtained using PET/CT and hysterectomy pathology specimens were recorded.Results:Tumor size (p=0.051) and volume (p=0.404) were not found to be correlated with the imaging method used in premenopausal women and pathologic specimens. However, there was a correlation in postmenopausal women (p<0.001 for tumor size and p<0.001 for tumor volume). PET/CT has higher sensitivity, specificity, and positive predictive value in the postmenopausal period in the detection of >20 mm uterine tumors.Conclusion:PET/CT has a limited role in the measurement of the size of uterine lesions in all patients, especially in the premenopausal period; therefore, we recommend that frozen-section examinations be used intraoperatively to decide on lymph node dissection.
Highlights
Endometrial cancer is the most common gynecologic malignancy in developed countries[1,2,3]
Objective: We aimed to investigate the correlation of the size and volume of uterine tumors obtained using positron emission tomography/computed tomography (PET/CT) and pathology specimens in patients with endometrioid-type endometrial cancer (EEC) in the premenopausal period, and to compare the results with those of postmenopausal women
PET/CT has a limited role in the measurement of the size of uterine lesions in all patients, especially in the premenopausal period; we recommend that frozen-section examinations be used intraoperatively to decide on lymph node dissection
Summary
Endometrial cancer is the most common gynecologic malignancy in developed countries[1,2,3]. Fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/CT) is an imaging modality used to obtain anatomic and metabolic data on cancer cells in numerous malignancies[2,3]. About 25% of patients with endometrioid-type endometrial cancer (EEC) are in the premenopausal periods[5]. Normal uptake of 18F-FDG PET/CT in patients who are premenopausal varies cyclically and increases in the ovulatory and menstrual phases[7]. We aimed to investigate the correlation of the size and volume of uterine tumors obtained using PET/ CT and pathology specimens in patients with EEC in the premenopausal period and to compare the results with those of postmenopausal women
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