Abstract
Purpose: The purpose of this study is to evaluate the sensitivity and positive predictive value (PPV) of the inflammatory bowel disease (IBD) serology 7 panel as a diagnostic aid in the evaluation of IBD. Methods: We performed a retrospective observational study to evaluate the sensitivity and PPV of the IBD serology 7 panel in diagnosing ulcerative colitis (UC), crohn's disease (CD) and IBD overall. Using administrative data from an integrated healthcare delivery system, we identified all patients who were tested for the IBD serology 7 panel from June 2007 through August 2008. Patients younger than 18 years old were excluded. Data extracted from patient records included age, sex, race, results of endoscopic procedures (esophagogastroduodenoscopy and colonoscopy) and concomitant pathology. The sensitivity and PPV was calculated with the use of 2x2 tables. Results: We identified 54 patients who had the IBD serology 7 panel tested from June 2007 through August 2008. The group consisted of 37.3% males, 57.4% Caucasian and a mean age of 46.2 years (range 18-88 years). For diagnosing UC, the sensitivity and PPV was calculated to be 50.0% and 89.4% (see Table 1). For diagnosing CD, the sensitivity and PPV was calculated to be 33.3% and 45.4%. The sensitivity and PPV for diagnosing IBD overall was calculated to be 71.8% and 90.3%.Table 1Conclusion: The sensitivity of the IBD serology 7 panel in diagnosing IBD overall, UC, or CD appears to be poor. The PPV for IBD overall and UC are strong while the PPV for CD is poor. The sensitivities calculated in this study vary greatly from the advertised performance of the IBD serology 7 panel (see Table 2). However, the calculated PPV are in adherence to the advertized performance with the exception of CD. Limitations include lack of testing in healthy individuals, inability to calculated specificity and negative predictive value, and lack of power.Table 2: Advertised performance of IBD serology 7 panel
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