Abstract
Epstein-Barr virus (EBV), a gammaherpesvirus infecting >90% of the world's population, is a recognized oncogenic agent. First discovered in a case of endemic (African) Burkitt's lymphoma (BL) (1), it has since been linked to a list of other human malignancies, including nasopharyngeal carcinoma, diffuse large cell lymphoma in immunocompromised individuals, in particular AIDS patients and transplant recipients, approximately half of all cases of Hodgkin's lymphoma, and, more recently, a significant percentage of gastric cancer (reviewed in refs. 2 and 3). Although considerable progress has been made in our understanding of how EBV causes cancer, and why such a widely distributed carcinogen does so in only a comparatively small number of infected individuals, many facets remain only poorly understood. In this issue of PNAS, Gruhne et al. (4) report observations that make an old acquaintance appear in a new light.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
