Is the distribution of cortical bone in the mandibular corpus and symphysis linked to loading environment in modern humans? A systematic review

Abstract

ObjectiveThe human mandible is a unique bone with specific external and internal morphological characteristics, influenced by a complex and challenging loading environment. Mandibular cortical thickness distribution in cross-sections is reported to be related to facial divergence patterns, cultural and dietary habits and more generally, specific loading environment. This review hypothesises that a process of environmental mechanical sensitivity is involved in the distribution of cortical bone in the mandibular corpus and symphysis in modern humans, and that loading regimes can influence this distribution pattern. Based on a review of the recent literature, this study aims to answer the following question: “Is the distribution of cortical bone in the mandibular corpus and symphysis linked to the loading environment in modern humans?” DesignA systematic review was undertaken using the PubMed/Medline, Scopus and Cochrane Library databases for publications from 1984 to 2022 investigating the relationship between cortical bone distribution in the mandibular corpus and the loading environment. A subgroup meta-analysis was performed to determine the overall effect of facial divergence on cortical thickness. ResultsFrom a total of 2791 studies, 20 fulfilled the inclusion criteria. The meta-analyses were performed in eight studies using a randomised model, finding a significant overall effect of facial divergence on cortical thickness in posterior areas of the mandible (p < 0.01). ConclusionsWithin the limitations of this review, specific loading regimes and their consequent variables (diet, culture, facial divergence) were linked to cortical thickness distribution. Sex was found to be unrelated to cortical thickness pattern.