Abstract
Brainstem CA neurons play an important role in the maturation and modulation of respiration. In adult mammals, CA system modulates the hypoxic and hypercapnic drive to breath. We evaluated the role of central CA neurons of male and female neonatal rats (P7-8) in the hypercapnic and hypoxic ventilatory response (HCVR/HVR) by specifically lesioning CA neurons using antidopamine beta-hydroxylase-saporin (DBH-SAP, 42ng / 100nL) injected into the 4th ventricle. Minute ventilation (VE) was recorded by pressure-plethysmography from the body chamber during normoxia, hypercapnia (7%CO2) and hypoxia (10%O2). The HCVR was significantly reduced in male (53%) and female (58%) lesioned neonatal rats (male- control group: 204.7±6.1 vs. lesioned group: 151.1±7.6, p<0.001; female- control group: 210.5±13.9 vs. lesioned group: 152.6±9.1, p<0.001; all values relative to % of baseline). In Addition, a similar reduction was observed in the HVR (male- control group: 169.3±7.1 vs. lesioned group: 109.6±6.9 , p<0.001; female- control group: 163.7±3.8 vs. lesioned group: 129.2±4.7, p<0.001; all values relative to % of baseline). These results suggest that central CA neurons exert an important excitatory modulation in CO2 and O2 chemosensitivity in neonates (P7-8). Financial support: FAPESP and CNPq
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