Is the benzodiazepine/GABA receptor chloride ionophore complex involved in physical and emotional stress?

Abstract

The response of an organism to physical and emotional stressors requires a complex integration of somatic, endocrine and behavioral systems. While causal relationships between specific receptor/effector systems in the central nervous system (CNS) and stress-induced somatic, endocrine and behavioral responses have not been firmly established, both physical and emotional stressors have been shown to affect a variety of neurotransmitters, neuromodulators, second messenger systems, and their associated recognition sites in the CNS (this volume and [1] for overviews). Thus, it is not surprising that most schemata describing stress-induced alterations in the CNS focus on the hypothalamus, although both the control and generation of stress must be initiated in higher centers.KeywordsChloride ChannelGaba ReceptorSupramolecular ComplexApparent AffinityHabituation PeriodThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.