Abstract
Background: Chronic obstructive pulmonary disease (COPD) is frequently associated with exertional oxygen desaturation, which may be evaluated using the 6-minute walking test (6MWT). However, it is a time-consuming test. The 1-minute sit-to-stand test (1STST) is a simpler test, already used to evaluate the functional status. The aim of this study was to compare the 1STST to the 6MWT in the evaluation of exertional desaturation. Methods: This was a cross-sectional study including 30 stable COPD patients who performed the 6MWT and 1STST on the same day. Six-minute walking distance (6MWD), number of 1STST repetitions (1STSTr), and cardiorespiratory parameters were recorded. Results: A significant correlation was found between the 6MWD and the number of 1STSTr (r = 0.54; p = 0.002). The minimum oxygen saturation (SpO2) in both tests showed a good agreement (intraclass correlation coefficient (ICC) 0.81) and correlated strongly (r = 0.84; p < 0.001). Regarding oxygen desaturation, the total agreement between the tests was 73.3% with a fair Cohen’s kappa (κ = 0.38; p = 0.018), and 93.33% of observations were within the limits of agreement for both tests in the Bland–Altman analysis. Conclusion: The 1STST seems to be a capable tool of detecting exercise-induced oxygen desaturation in COPD. Because it is a less time- and resources-consuming test, it may be applied during the outpatient clinic consultation to regularly evaluate the exercise capacity and exertional desaturation in COPD.
Highlights
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with an economic and social burden that is both substantial and increasing [1]
Most patients were included in the moderate-to-severe Global Initiative for Chronic Obstructive Lung Disease (GOLD) category [1] (GOLD 1: 1 (3.3%), GOLD 2: 16 (53.3%), GOLD 3: 12 (40%), GOLD 4: 1 (3.3%))
Our study established that the 1-minute sit-to-stand test (1STST) seems to be a reliable test to estimate exercise-induced oxygen desaturation in COPD, as demonstrated by the existence of a strong correlation and agreement between minimum SpO2 in the 1STST and in the 6-minute walking test (6MWT) and a good total concordance between oxygen desaturation recorded during both tests
Summary
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with an economic and social burden that is both substantial and increasing [1]. The 6-minute walking test (6MWT) is considered a validated and reliable test to evaluate the cardiopulmonary and musculoskeletal function in COPD [4]. Chronic obstructive pulmonary disease (COPD) is frequently associated with exertional oxygen desaturation, which may be evaluated using the 6-minute walking test (6MWT). Conclusion: The 1STST seems to be a capable tool of detecting exercise-induced oxygen desaturation in COPD Because it is a less time- and resources-consuming test, it may be applied during the outpatient clinic consultation to regularly evaluate the exercise capacity and exertional desaturation in COPD
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